Publications

A complete list is on PubMed, Google Scholar, and ORCID. Each entry below links to its DOI and PubMed record.

01Preprints2

  1. Striepen J, Dananberg A, Ruzgaitė A, Hurley A, Toufektchan E, Nichols A, Rosenberg H, Cordero C, Mertz TM, Norman RX, Koche R, Roberts SA, Maciejowski J. Squamous-state excursions activate APOBEC3A in cancer. bioRxiv 2026.DOIPubMed 42244601
  2. Striepen J, Culibrk L, Dananberg A, Rozowsky JS, Petljak M, Maciejowski J. A context dependent hierarchy of APOBEC3A and APOBEC3B mutators in lung adenocarcinoma. bioRxiv 2026.DOI

02Maciejowski Lab18

  1. Chen Y, Norman RX, Toufektchan E, Luan X, Shim A, Rosenberg H, Kovacs MT, Nichols A, Hickling J, Cifani P, Kentsis A, Zhou W, Maciejowski J. ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei. Molecular Cell 2026;86(6):1099–1115.DOIPubMed 41861785
  2. Nichols A, Salataj E, Choi Y, Hamard PJ, Koche R, Maciejowski J. Protocol for the generation of low-input Hi-C sequencing libraries of FACS-isolated mitotic cells. STAR Protocols 2025;6(4):104241.DOIPubMed 41317326
  3. Nichols A, Choi Y, Norman RX, Chen Y, Striepen J, Salataj E, Toufektchan E, Koche R, Maciejowski J. Chromosomal tethering and mitotic transcription promote ecDNA nuclear inheritance. Molecular Cell 2025;85(15):2839–2853.DOIPubMed 40614723
  4. Ortega P, Bournique E, Li J, Sanchez A, Santiago G, Harris BR, Striepen J, Maciejowski J, Green AM, Buisson R. Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe. Science Advances 2025;11(16):eadu0437.DOIPubMed 40238882
  5. Raeisi Dehkordi S, Wong ITL, Ni J, Luebeck J, Zhu K, Prasad G, Krockenberger L, Xu G, Chowdhury B, Rajkumar U, Caplin A, Muliaditan D, Gnanasekar A, Coruh C, Jin Q, Turner K, Teo SX, Pang AWC, Alexandrov LB, Chua CEL, Furnari FB, Maciejowski J, Paulson TG, Law JA, Chang HY, Yue F, DasGupta R, Zhao J, Mischel PS, Bafna V. Breakage fusion bridge cycles drive high oncogene number with moderate intratumoural heterogeneity. Nature Communications 2025;16:1497.DOIPubMed 39929823
  6. Karasu ME, Toufektchan E, Chen Y, Albertelli A, Cullot G, Maciejowski J, Corn JE. Removal of TREX1 activity enhances CRISPR-Cas9-mediated homologous recombination. Nature Biotechnology 2025;43(7):1168–1176.DOIPubMed 39134754
  7. Di Bona M, Chen Y, Agustinus AS, Mazzagatti A, Duran MA, Deyell M, Bronder D, Hickling J, Hong C, Scipioni L, Tedeschi G, Martin S, Li J, Ruzgaitė A, Riaz N, Shah P, D'Souza EK, Brodtman DZ, Sidoli S, Diplas B, Jalan M, Lee NY, Ordureau A, Izar B, Laughney AM, Powell S, Gratton E, Santaguida S, Maciejowski J, Ly P, Jeitner TM, Bakhoum SF. Micronuclear collapse from oxidative damage. Science 2024;385(6712):eadj8691.DOIPubMed 39208110
  8. Shim A, Luan X, Zhou W, Crow YJ, Maciejowski J. Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling. Human Molecular Genetics 2024;33(18):1555–1566.DOIPubMed 38796715
  9. Toufektchan E, Dananberg A, Striepen J, Hickling JH, Shim A, Chen Y, Nichols A, Duran Paez MA, Mohr L, Bakhoum SF, Maciejowski J. Intratumoral TREX1 induction promotes immune evasion by limiting type I IFN. Cancer Immunology Research 2024;12(6):673–686.DOIPubMed 38408184
  10. Dananberg A, Maciejowski J. Monitoring APOBEC3A protein levels in human cancer cells. Methods in Cell Biology 2024;182:313–327.DOIPubMed 38359985
  11. Coxon M, Dennis MA, Dananberg A, Collins CD, Wilson HE, Meekma J, Savenkova MI, Ng D, Osbron CA, Mertz TM, Goodman AG, Duttke SH, Maciejowski J, Roberts SA. An impaired ubiquitin-proteasome system increases APOBEC3A abundance. NAR Cancer 2023;5(4):zcad058.DOIPubMed 38155930
  12. Agustinus AS, Al-Rawi D, Dameracharla B, Raviram R, Jones BSCL, Stransky S, Scipioni L, Luebeck J, Di Bona M, Norkunaite D, Myers RM, Duran M, Choi S, Weigelt B, Yomtoubian S, McPherson A, Toufektchan E, Keuper K, Mischel PS, Mittal V, Shah SP, Maciejowski J, Storchova Z, Gratton E, Ly P, Landau D, Bakhoum MF, Koche RP, Sidoli S, Bafna V, David Y, Bakhoum SF. Epigenetic dysregulation from chromosomal transit in micronuclei. Nature 2023;619(7968):176–183.DOIPubMed 37286593
  13. Petljak M, Dananberg A, Chu K, Bergstrom EN, Striepen J, von Morgen P, Chen Y, Shah H, Sale JE, Alexandrov LB, Stratton MR, Maciejowski J. Mechanisms of APOBEC3 mutagenesis in human cancer cells. Nature 2022;607(7920):799–807.DOIPubMed 35859169
  14. Toufektchan E, Maciejowski J. Purification of micronuclei from cultured cells by flow cytometry. STAR Protocols 2021;2(1):100378.DOIPubMed 33778777
  15. Oh S, Bournique E, Bowen D, Jalili P, Sanchez A, Ward I, Dananberg A, Manjunath L, Tran GP, Semler BL, Maciejowski J, Seldin M, Buisson R. Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways. Nature Communications 2021;12(1):4917.DOIPubMed 34389714
  16. Mohr L, Toufektchan E, von Morgen P, Chu K, Kapoor A, Maciejowski J. ER-directed TREX1 limits cGAS activation at micronuclei. Molecular Cell 2021;81(4):724–738.DOIPubMed 33476576
  17. Zhou W, Mohr L, Maciejowski J, Kranzusch PJ. cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing. Molecular Cell 2021;81(4):739–755.DOIPubMed 33606975
  18. Hadi K, Yao X, Behr JM, Deshpande A, Xanthopoulakis C, Tian H, Kudman S, Rosiene J, Darmofal M, DeRose J, Mortensen R, Adney EM, Shaiber A, Gajic Z, Sigouros M, Eng K, Wala JA, Wrzeszczyński KO, Arora K, Shah M, Emde AK, Felice V, Frank MO, Darnell RB, Ghandi M, Huang F, Dewhurst S, Maciejowski J, de Lange T, Setton J, Riaz N, Reis-Filho JS, Powell S, Knowles DA, Reznik E, Mishra B, Beroukhim R, Zody MC, Robine N, Oman KM, Sanchez CA, Kuhner MK, Smith LP, Galipeau PC, Paulson TG, Reid BJ, Li X, Wilkes D, Sboner A, Mosquera JM, Elemento O, Imielinski M. Distinct classes of complex structural variation uncovered across thousands of cancer genome graphs. Cell 2020;183(1):197–210.DOIPubMed 33007263

03Reviews and commentaries10

  1. Shim A, Chen Y, Maciejowski J. Activation and regulation of cGAS-STING signaling in cancer cells. Molecular Cell 2025;85(20):3807–3822.DOIPubMed 41106370
  2. Maciejowski J, Greenberg RA. Transactions on micronuclear DNA and implications for immune signaling. Trends in Biochemical Sciences 2025.DOIPubMed 41271538
  3. Maciejowski J, Mohamed T. APOBEC3 upregulation drives gemcitabine resistance. Nature Cancer 2024;5(6):818–820.DOIPubMed 38778178
  4. Toufektchan E, Maciejowski J. Feeding two birds with one scone: the dual roles of SMARCAL1 in antitumor immunity. Molecular Cell 2024;84(5):819–821.DOIPubMed 38458172
  5. Petljak M, Green AM, Maciejowski J, Weitzman MD. Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer. Nature Genetics 2022;54(11):1599–1608.DOIPubMed 36280735
  6. Petljak M, Maciejowski J. Molecular origins of APOBEC-associated mutations in cancer. DNA Repair 2020;94:102905.DOIPubMed 32818816
  7. Maciejowski J, Hatch EM. Nuclear membrane rupture and its consequences. Annual Review of Cell and Developmental Biology 2020;36:85–114.DOIPubMed 32692592
  8. von Morgen P, Maciejowski J. The ins and outs of telomere crisis in cancer. Genome Medicine 2018;10(1):89.DOIPubMed 30482235
  9. Maciejowski J, de Lange T. Telomeres in cancer: tumour suppression and genome instability. Nature Reviews Molecular Cell Biology 2017;18(3):175–186.DOIPubMed 28096526
  10. Maciejowski J, Imielinski M. Modeling cancer rearrangement landscapes. Current Opinion in Systems Biology 2017;1:54–61.DOIPubMed 29177203

04Postdoctoral work4

  1. Maciejowski J, Chatzipli A, Dananberg A, Chu K, Toufektchan E, Klimczak LJ, Gordenin DA, Campbell PJ, de Lange T. APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis. Nature Genetics 2020;52(9):884–890.DOIPubMed 32719516
  2. Yang Z, Maciejowski J, de Lange T. Nuclear envelope rupture is enhanced by loss of p53 or Rb. Molecular Cancer Research 2017;15(11):1579–1586.DOIPubMed 28811362
  3. McIntyre RE, Nicod J, Robles-Espinoza CD, Maciejowski J, Cai N, Hill J, Verstraten R, Iyer V, Rust AG, Balmus G, Mott R, Flint J, Adams DJ. A genome-wide association study for regulators of micronucleus formation in mice. G3 2016;6(8):2343–2354.DOIPubMed 27233670
  4. Maciejowski J, Li Y, Bosco N, Campbell PJ, de Lange T. Chromothripsis and kataegis induced by telomere crisis. Cell 2015;163(7):1641–1654.DOIPubMed 26687355

05Graduate and earlier work10

  1. Rodriguez-Rodriguez JA, Lewis C, McKinley KL, Sikirzhytski V, Corona J, Maciejowski J, Khodjakov A, Cheeseman IM, Jallepalli PV. Distinct roles of RZZ and Bub1-KNL1 in mitotic checkpoint signaling and kinetochore expansion. Current Biology 2018;28(21):3422–3429.DOIPubMed 30415700
  2. Combes G, Barysz H, Garand C, Gama Braga L, Alharbi I, Thebault P, Murakami L, Bryne DP, Stankovic S, Eyers PA, Bolanos-Garcia VM, Earnshaw WC, Maciejowski J, Jallepalli PV, Elowe S. Mps1 phosphorylates its N-terminal extension to relieve autoinhibition and activate the spindle assembly checkpoint. Current Biology 2018;28(6):872–883.DOIPubMed 29502948
  3. Maciejowski J, Drechsler H, Grundner-Culemann K, Ballister ER, Rodriguez-Rodriguez JA, Rodriguez-Bravo V, Jones MJK, Foley E, Lampson MA, Daub H, McAinsh AD, Jallepalli PV. Mps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation. Developmental Cell 2017;41(2):143–156.DOIPubMed 28441529
  4. Rodriguez-Bravo V, Maciejowski J, Corona J, Buch HK, Collin P, Kanemaki MT, Shah JV, Jallepalli PV. Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor. Cell 2014;156(5):1017–1031.DOIPubMed 24581499
  5. Paschal CR, Maciejowski J, Jallepalli PV. A stringent requirement for Plk1 T210 phosphorylation during K-fiber assembly and chromosome congression. Chromosoma 2012;121(6):565–572.DOIPubMed 22566210
  6. Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. Journal of Cell Biology 2010;190(1):89–100.DOIPubMed 20624902
  7. McGovern M, Voutev R, Maciejowski J, Corsi AK, Hubbard EJA. A "latent niche" mechanism for tumor initiation. Proceedings of the National Academy of Sciences 2009;106(28):11617–11622.DOIPubMed 19564624
  8. Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biology 2009;7(5):e1000111.DOIPubMed 19468302
  9. Maciejowski J, Ugel N, Mishra B, Isopi M, Hubbard EJA. Quantitative analysis of germline mitosis in adult C. elegans. Developmental Biology 2006;292(1):142–151.DOIPubMed 16480707
  10. Maciejowski J, Ahn JH, Cipriani PG, Killian DJ, Chaudhary AL, Lee JI, Voutev R, Johnsen RC, Baillie DL, Gunsalus KC, Fitch DHA, Hubbard EJA. Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans. Genetics 2005;169(4):1997–2011.DOIPubMed 15687263