Research
We study genomic instability in cancer: how tumors manage the immune consequences of their own broken chromosomes, and what that instability writes into the cancer genome. Three lines of work, one origin.
01
Extrachromosomal DNA
Oncogenes amplified on circular DNA that has no centromere, and how those circles survive cell division anyway.
02APOBEC3A mutagenesis and cell state
An enzyme responsible for a large share of the point mutations in human cancer, and the rare cell state that switches it on.
03Genomic instability and innate immunity
How cells detect their own DNA when it escapes into the cytoplasm, and how tumors keep that from happening.